CERTH is a unique Research Center with its 5 Institutes (Chemical Process & Energy Resources Institute – CPERI, Information Technologies Institute –ITI, Hellenic Institute of Transport – HIT, Institute of Applied Biosciences – INAB , Bio-economy and Agro-Technology Institute – IBO) being present in 6 regions and 8 cities. CERTH is essentially a self-supported Research Centre generating a turnover of over € 44,5 Million in the last year (2021), employing more than 1200 people, the majority being engineers and scientists. CERTH is a unique Centre of research excellence and innovation performance. It has been ranked in the 14th position among the EU Research Centres in terms of H2020 net EU Contribution and has received numerous awards and distinctions (including: EU Descartes Prize, ERC Advanced Grant, NATO (NCI Agency) data contest 1st and 3rd prizes, Top Scientists ranking for computer science based on the H-Index metric, etc.). CERTH has unique infrastructures at the lab, pilot and demonstration scales in Energy, Environment, Sustainable Mobility, ICT, Processes & Manufacturing, Agritech, Biosciences/Biotech fields. In addition, CERTH has great ability to innovate as indicated by the numerous industrial collaborations with worldwide acknowledged companies (14% of its annual income derives from bilateral industrial research projects) and the development of innovative entrepreneurship (18 spin off companies currently operating).